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Mean plasma APAP concentrations after single-dose administration of IR/ER HB/APAP or IR <t>tramadol</t> HCl/APAP. Abbreviations: APAP, acetaminophen; ER, extended-release; HB, hydrocodone bitartrate; HCl, hydrochloride; IR, immediate release.
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Mean plasma APAP concentrations after single-dose administration of IR/ER HB/APAP or IR tramadol HCl/APAP. Abbreviations: APAP, acetaminophen; ER, extended-release; HB, hydrocodone bitartrate; HCl, hydrochloride; IR, immediate release.

Journal: Journal of Pain Research

Article Title: Single- and multiple-dose pharmacokinetics of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) compared with immediate-release hydrocodone bitartrate/ibuprofen and immediate-release tramadol HCl/acetaminophen

doi: 10.2147/JPR.S83416

Figure Lengend Snippet: Mean plasma APAP concentrations after single-dose administration of IR/ER HB/APAP or IR tramadol HCl/APAP. Abbreviations: APAP, acetaminophen; ER, extended-release; HB, hydrocodone bitartrate; HCl, hydrochloride; IR, immediate release.

Article Snippet: This study examined the single-dose and steady-state pharmacokinetic (PK) profile of IR/ER HB/APAP compared with two IR FDC analgesics available for the treatment of acute pain, IR HB/ibuprofen (Vicoprofen ® ; Halo Pharmaceutical Inc., Whippany, NJ, USA) and IR tramadol HCl/APAP (Ultracet ® ; PriCare Division of Janssen Ortho Pharmaceuticals Inc., Gurabo, PR, USA), in healthy volunteers under fasted conditions.

Techniques: Clinical Proteomics

Pharmacokinetic estimates for APAP after single-dose administration of IR/ER HB/APAP (n=27–30; also look at individual footnotes given in the first column) <xref ref-type= a " width="100%" height="100%">

Journal: Journal of Pain Research

Article Title: Single- and multiple-dose pharmacokinetics of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) compared with immediate-release hydrocodone bitartrate/ibuprofen and immediate-release tramadol HCl/acetaminophen

doi: 10.2147/JPR.S83416

Figure Lengend Snippet: Pharmacokinetic estimates for APAP after single-dose administration of IR/ER HB/APAP (n=27–30; also look at individual footnotes given in the first column) a

Article Snippet: This study examined the single-dose and steady-state pharmacokinetic (PK) profile of IR/ER HB/APAP compared with two IR FDC analgesics available for the treatment of acute pain, IR HB/ibuprofen (Vicoprofen ® ; Halo Pharmaceutical Inc., Whippany, NJ, USA) and IR tramadol HCl/APAP (Ultracet ® ; PriCare Division of Janssen Ortho Pharmaceuticals Inc., Gurabo, PR, USA), in healthy volunteers under fasted conditions.

Techniques:

Mean steady-state plasma APAP concentrations after multiple-dose administration of IR/ER HB/APAP or IR tramadol HCl/APAP. Abbreviations: APAP, acetaminophen; ER, extended-release; HB, hydrocodone bitartrate; HCl, hydrochloride; IR, immediate-release; q6h, every 6 hours; q12h, every 12 hours.

Journal: Journal of Pain Research

Article Title: Single- and multiple-dose pharmacokinetics of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) compared with immediate-release hydrocodone bitartrate/ibuprofen and immediate-release tramadol HCl/acetaminophen

doi: 10.2147/JPR.S83416

Figure Lengend Snippet: Mean steady-state plasma APAP concentrations after multiple-dose administration of IR/ER HB/APAP or IR tramadol HCl/APAP. Abbreviations: APAP, acetaminophen; ER, extended-release; HB, hydrocodone bitartrate; HCl, hydrochloride; IR, immediate-release; q6h, every 6 hours; q12h, every 12 hours.

Article Snippet: This study examined the single-dose and steady-state pharmacokinetic (PK) profile of IR/ER HB/APAP compared with two IR FDC analgesics available for the treatment of acute pain, IR HB/ibuprofen (Vicoprofen ® ; Halo Pharmaceutical Inc., Whippany, NJ, USA) and IR tramadol HCl/APAP (Ultracet ® ; PriCare Division of Janssen Ortho Pharmaceuticals Inc., Gurabo, PR, USA), in healthy volunteers under fasted conditions.

Techniques: Clinical Proteomics